ISMO – Université Paris Saclay
Internship for 1st or 2nd year Master.
Vibrational spectroscopy is a tool of choice for probing the non-covalent molecular interactions that are at the center of interactions between biological molecules. In our laboratory, we have developed an expertise in the infrared (IR) spectroscopy of the elongation modes of the O-H, NH and O-D modes, in the gas phase. These modes, which absorb in the region of 2.5 to 4 um, are very important since they are at the center of these non-covalent interactions. For this purpose we have developed an IR-UV double resonance spectroscopy device in the near IR region. The proposed internship work consists in setting up a new double resonance laser spectroscopy setup to extend the accessible spectral range and obtain more information on large molecular structures. By a nonlinear optics approach based on frequency difference we will be able to observe the IR spectra over a range from 2.5 to 15 um. Another very promising approach will be based on Stimulated Raman double resonance spectroscopy – UV will give us access to even lower frequency modes. The new setup will be applied to observe the first mid-IR spectra of sugar based complex biomolecular assemblies and large hydrated clusters.